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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Fructuoso Noa | 1.723 | 1882-1895 | |
| 2 | Constancio Álvarez# | 1.750 | 1884-1897 | |
| 3 | Zeferino Duque | 1.909 | 1882-1891 | |
| 4 | Héctor López | 2.139 | 1878-1889 | |
| 5 | Juan Padilla | 2.221 | 1878-1883 | |
| 6 | Alfredo Cruz# | 2.314 | 1894-1897 | |
| 7 | Pío Martínez | 2.333 | 1880-1892 | |
| 8 | Ricardo Sánchez | 2.455 | 1887-1892 | |
| 9 | Flaminio Martínez | 2.526 | 1880-1894 | |
| 10 | Raúl Torres | 2.547 | 1882-1893 | |
| 11 | Jorge Vélez# | 2.553 | 1888-1897 | |
| 12 | Cleto Correa# | 2.719 | 1889-1897 | |
| 13 | Heliodoro Pérez | 2.783 | 1878-1889 | |
| 14 | Ludovico Andrade | 2.924 | 1878-1885 | |
| 15 | Romualdo Baca | 2.952 | 1887-1896 | |
| 16 | Alberto López# | 3.153 | 1891-1897 | |
| 17 | Bernal Echevana | 3.214 | 1890-1897 | |
| 18 | Eugenio Mendoza# | 3.247 | 1891-1892 | |
| 19 | José Barreto# | 3.297 | 1887-1897 | |
| 20 | Armando Sorto# | 3.493 | 1888-1897 | |
| 21 | Jesus Umana | 3.511 | 1878-1884 | |
| 22 | Curcio Cruz# | 3.600 | 1892-1897 | |
| 23 | Nemesio Hinojos# | 3.857 | 1889-1897 | |
| 24 | Afrodisio García | 3.892 | 1887-1896 | |
| 25 | Ernesto Cruz | 3.898 | 1878-1891 | |
| 26 | Ángel González# | 3.930 | 1895-1897 | |
| 27 | Matías Villarreal# | 3.971 | 1892-1897 | |
| 28 | Zenobio Rodríguez# | 3.996 | 1889-1897 | |
| 29 | Ignacio Barbosa | 4.006 | 1878-1883 | |
| 30 | Esteban Quiros# | 4.075 | 1890-1897 | |
| 31 | Francisco Cueva# | 4.097 | 1890-1897 | |
| 32 | Pandolfo Ortega# | 4.154 | 1884-1897 | |
| 33 | Ricardo Figueroa | 4.552 | 1882-1890 | |
| 34 | Juan Echeverría# | 5.218 | 1887-1897 | |
| 35 | Julio César López# | 5.659 | 1893-1897 |
